Research foci of the BMT Program are in the areas of multiple myeloma, lymphoma, myelofibrosis, and supportive care. Active clinical BMT studies include the following:

1. A prospective study to evaluate the performance and complications of vascular access devices in patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation. (C. Freytes, co-investigator)
2. Double-blind, Randomized, Multicenter Trial Comparing 2 Schedules of CGP 46614 and placebo to prevent/alleviate chemotherapy induced oral mucositis in patients with lymphoma, cancer of the breast or other solid tumors, who receive preparatory chemotherapy for autologous bone marrow transplantation or stem cell transfusion. (C. Freytes, co-investigator)
3. Phase I/II Dose Escalation of Trial of Paclitaxel Incorporated into High-Dose Cyclophosphamide, Carmustine (BCNU), and Etoposide Phosphate (VP-16 Phosphate) (CBV) with Autologous Bone Marrow or Peripheral Stem Cell Support in Patients with Relapsed, Refractory or High Risk Hodgkins Disease or Non-Hodgkin's Lymphoma. (C. Freytes, PI) 4) Randomized Study of Peripheral Blood Stem Cell Mobilization with Cyclophosphamide in Combination with G-CSF GM-CSF, or sequential GM-CSF Followed by G-CSF in Non-Hodgkin's Lymphoma Patients. (N. Callander and Y. Gazitt, Co-PIs) 5) A Pilot Study of the Effect of Pamidronate on Peripheral Stem Cell Mobilization in Patients Undergoing Autologous Bone Marrow Transplant for Multiple Myeloma. (N. Callander and Y. Gazitt, co-PIs)
4. A Prospective Randomized Phase III Study Using CEPRATE SC Stem Cell Concentrator to Concentrate Hematopoietic Progenitors For Use in Hematopoietic Support After High Dose Chemotherapy. (C. Freytes, co-investigator)

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