FACULTY PROFILE

DAVID H. BOLDT, M.D.

Gokmen E, Raaphorst FM, Boldt DH, Teale JM.  Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization. Blood 92:2802-2814, 1998.

Boldt DH New Perspectives on Iron. New Perspectives on Iron. Am J Med Sci 1999 Oct;318(4):207-12.

Stock W, Tsai T, Golden C, Rankin C, Sher D, Slovak ML, Pallavicini MG, Boldt DH.  Cell cycle regulatory gene abnormalities are important determinants of leukemogenesis and disease biology in adult acute lymphoblastic leukemia.  Blood 2000 April 1(95)7:2364-71

Rosen PJ, Rankin C, Head DR, Boldt DH, Luthardt FW, Norwood T, Pugh RP, Flaherty LE, Appelbaum FR.  A Phase II study of high dose Ara-C and Mitoxantrone for treatment of relapsed or refractory adult acute lymphoblastic leukemia.  A Southwest Oncology Group study.  Leuk Res 2000 Mar;24(3):183-7

Reddy SV, Alcantara O, Boldt DH. Analysis of DNA binding proteins associated with hemin-induced transcriptional inhibition.  The hemin response element binding protein (HREBP) is a heterogeneous complex that includes the Ku protein.  Blood 91:1793-1801, 1998.

Petersdorf SH, Kopecky KJ, Head DR, Boldt DH, Balcerzak SP, Wun T, Roy V, Veith RW, Appelbaum FR.  Comparison of the L10M consolidation regimen to an alternative regimen including escalating methotrexate/L-asparaginase for adult acute lymphoblastic leukemia: a Southwest Oncology Group Study.
Leukemia. 2001 Feb;15(2):208-16.

Gazitt Y, Reddy SV, Alcantara O, Yang J, Boldt DH.

A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate.
J Cell Physiol. 2001 Apr;187(1):124-35.

Alcantara, O., Kalidas, M., Baltathakis, I., and Boldt, D.H.,  Expression of multiple genes regulating cell cycle and apoptosis in differentiating hematopoietic cells is dependent on iron.  Exptl.  Hematol., in press, 2001.

Baltathakis, I., Alcantara, O., Boldt, D.H.  Expression of different NF-kB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling.  J. Cell. Biochem., in press, 2001.